Keywords
MeSH Terms
Affiliated Institutions
Related Publications
Pan-cancer single-cell landscape of tumor-infiltrating T cells
An atlas of cancer-associated T cells The tumor microenvironment contains many different kinds of immune cells, the composition, function, and roles of which are unclear. Using ...
VEGF-A modulates expression of inhibitory checkpoints on CD8+ T cells in tumors
Immune escape is a prerequisite for tumor development. To avoid the immune system, tumors develop different mechanisms, including T cell exhaustion, which is characterized by ex...
PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
Vaccination with irradiated B16 melanoma cells expressing either GM-CSF (Gvax) or Flt3-ligand (Fvax) combined with antibody blockade of the negative T-cell costimulatory recepto...
Immune cells within the tumor microenvironment: Biological functions and roles in cancer immunotherapy
The immune cells within the tumor microenvironment (TME) play important roles in tumorigenesis. It has been known that these tumor associated immune cells may possess tumor-anta...
Tumor Rejection After Direct Costimulation of CD8 <sup>+</sup> T Cells by B7-Transfected Melanoma Cells
A variety of tumors are potentially immunogenic but do not stimulate an effective anti-tumor immune response in vivo. Tumors may be capable of delivering antigen-specific signal...
Publication Info
- Year
- 2020
- Type
- review
- Volume
- 20
- Issue
- 4
- Pages
- 218-232
- Citations
- 1443
- Access
- Closed
External Links
Social Impact
Social media, news, blog, policy document mentions
Citation Metrics
Cite This
Identifiers
- DOI
- 10.1038/s41568-019-0235-4
- PMID
- 32024970
- PMCID
- PMC7115982