Abstract
A variety of tumors are potentially immunogenic but do not stimulate an effective anti-tumor immune response in vivo. Tumors may be capable of delivering antigen-specific signals to T cells, but may not deliver the costimulatory signals necessary for full activation of T cells. Expression of the costimulatory ligand B7 on melanoma cells was found to induce the rejection of a murine melanoma in vivo. This rejection was mediated by CD8 + T cells; CD4 + T cells were not required. These results suggest that B7 expression renders tumor cells capable of effective antigen presentation, leading to their eradication in vivo.
Keywords
Cytotoxic T cellMelanomaIn vivoCD8AntigenImmune systemCancer researchCD40TransfectionAntigen-presenting cellAntigen presentationImmunotherapyBiologyTumor antigenImmunologyT cellIn vitroCell culture
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Publication Info
- Year
- 1993
- Type
- article
- Volume
- 259
- Issue
- 5093
- Pages
- 368-370
- Citations
- 1140
- Access
- Closed
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Cite This
Sarah E. Townsend,
James P. Allison
(1993).
Tumor Rejection After Direct Costimulation of CD8 <sup>+</sup> T Cells by B7-Transfected Melanoma Cells.
Science
, 259
(5093)
, 368-370.
https://doi.org/10.1126/science.7678351
Identifiers
- DOI
- 10.1126/science.7678351