Caspase-11 Protects Against Bacteria That Escape the Vacuole

Abstract

Caspase-11–Dependent Pyroptosis Inflammasomes are multiprotein complexes that assemble to initiate immunity to a variety of microorganisms, as well as to sterile tissue injury. Although a role for caspase-1 downstream of inflammasomes is well characterized, the discovery that caspase-1 knockout mice were also deficient in caspase-11 has led to a reassessment of the function of caspase-11. Aachoui et al. (p. 975 , published online 24 January; see the Perspective by Cemma and Brumell ) now demonstrate that caspase-11 is required for immunity against cytosolic bacteria in mice. Only bacteria that were able to access cytosol-activated caspase-11–dependent pyroptosis, an inflammatory type of cell death. This function of caspase-11 appeared to be independent of canonical inflammasomes.

Keywords

PyroptosisCaspaseCell biologyCytosolCaspase 1InflammasomeBiologyImmunityBacteriaFunction (biology)Programmed cell deathChemistryApoptosisInflammationEnzymeBiochemistryImmunologyImmune systemGenetics

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Publication Info

Year: 2013
Type: article
Volume: 339
Issue: 6122
Pages: 975-978
Citations: 532
Access: Closed

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APA Style

                            
                                
                                    Youssef Aachoui, 
                                
                                    Irina A. Leaf, 
                                
                                    Jon A. Hagar
                                
                                et al.
                            
                            (2013). 
                            Caspase-11 Protects Against Bacteria That Escape the Vacuole. 
                            Science
                            , 339
                            (6122)
                            , 975-978.
                            https://doi.org/10.1126/science.1230751
                        

Identifiers

DOI: 10.1126/science.1230751