Edward A. Miao

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

Caspase-11 Protects Against Bacteria That Escape the Vacuole

Caspase-11–Dependent Pyroptosis Inflammasomes are multiprotein complexes that assemble to initiate immunity to a variety of microorganisms, as well as to sterile tissue injury. ...

Programmed cell death as a defence against infection

Eukaryotic cells can die from physical trauma, which results in necrosis. Alternatively, they can die through programmed cell death upon the stimulation of specific signalling p...

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

Move Over, TLR4 The innate immune system senses bacterial lipopolysaccharide (LPS) through Toll-like receptor 4 (TLR4) (see the Perspective by Kagan ). However, Kayagaki et al. ...

Pyroptotic cell death defends against intracellular pathogens

Summary Inflammatory caspases play a central role in innate immunity by responding to cytosolic signals and initiating a twofold response. First, caspase‐1 induces the activatio...