Alan Aderem

Pyogenic Bacterial Infections in Humans with IRAK-4 Deficiency

Members of the Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) superfamily share an intracytoplasmic Toll–IL-1 receptor (TIR) domain, which mediates recruitment of t...

The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens

Macrophages orchestrate innate immunity by phagocytosing pathogens and coordinating inflammatory responses. Effective defence requires the host to discriminate between different...

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

Caspase-11 Protects Against Bacteria That Escape the Vacuole

Caspase-11–Dependent Pyroptosis Inflammasomes are multiprotein complexes that assemble to initiate immunity to a variety of microorganisms, as well as to sterile tissue injury. ...