Assessing the suitability of summary data for two-sample Mendelian randomization analyses using MR-Egger regression: the role of the I2 statistic

Abstract

: Care must be taken to assess the NOME assumption via the IGX2 statistic before implementing standard MR-Egger regression in the two-sample summary data context. If IGX2 is sufficiently low (less than 90%), inferences from the method should be interpreted with caution and adjustment methods considered.

Keywords

Mendelian randomizationRegressionStatisticStatisticsEconometricsMathematicsGeneticsBiologyGenetic variants

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Publication Info

Year: 2016
Type: article
Volume: 45
Issue: 6
Pages: dyw220-dyw220
Citations: 1670
Access: Closed

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APA Style

                            
                                
                                    Jack Bowden, 
                                
                                    Fabiola Del Greco M, 
                                
                                    Cosetta Minelli
                                
                                et al.
                            
                            (2016). 
                            Assessing the suitability of summary data for two-sample Mendelian randomization analyses using MR-Egger regression: the role of the I2 statistic. 
                            International Journal of Epidemiology
                            , 45
                            (6)
                            , dyw220-dyw220.
                            https://doi.org/10.1093/ije/dyw220
                        

Identifiers

DOI: 10.1093/ije/dyw220