Abstract

Cardiac output and intravascular pressure were measured before and after large doses of glucocorticosteroids administered intravenously to nine normal subjects and nine patients in shock. Glucocorticoids caused a sustained increase in cardiac output and a decrease in calculated peripheral resistance. No changes in mean arterial and venous pressures were observed. Possible mechanisms underlying these pharmacologic effects and their implications for the treatment of shock are discussed.

Keywords

MedicineShock (circulatory)PharmacodynamicsCardiac outputPeripheral resistancePeripheralCardiologyBlood pressureCentral venous pressureAnesthesiaInternal medicineHeart ratePharmacokinetics

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Publication Info

Year
1965
Type
article
Volume
31
Issue
4
Pages
523-530
Citations
125
Access
Closed

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Mohinder P. Sambhi, Max Harry Weil, Vasant N. Udhoji (1965). Acute Pharmacodynamic Effects of Glucocorticoids. Circulation , 31 (4) , 523-530. https://doi.org/10.1161/01.cir.31.4.523

Identifiers

DOI
10.1161/01.cir.31.4.523