Abstract

We find that a fraction of Ly-1+2- inducer T cell clones inhibits differentiation of memory B cells into IgG-secreting plaque-forming cells. Inhibition of secondary antibody responses was not the result of induction of Ly-2+ T suppressors. Instead, inducer cells directly inactivated B cells, requiring an antigen bridge as well as identity at the major histocompatibility complex (I-A) locus. The interaction between the inducer T cell clone and hapten-specific B memory cells results in an early proliferative response and subsequent failure of B cells to secrete antibody in response to T helper cell signals. Possible mechanisms for this novel type of B cell inactivation are explored.

Keywords

BiologyInducerclone (Java method)Molecular biologyB cellSecretionCell biologyMajor histocompatibility complexAntibodyAntigenT cellCellImmunologyImmune systemGeneticsGeneBiochemistry

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Publication Info

Year
1985
Type
article
Volume
161
Issue
4
Pages
785-804
Citations
16
Access
Closed

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Steven Friedman, Debbie Sillcocks, Anjana Rao et al. (1985). A subset of Ly-1 inducer T cell clones activates B cell proliferation but directly inhibits subsequent IgG secretion.. The Journal of Experimental Medicine , 161 (4) , 785-804. https://doi.org/10.1084/jem.161.4.785

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DOI
10.1084/jem.161.4.785