Reactive astrocyte nomenclature, definitions, and future directions
Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional remodeling in response to injury, disease, or infection of the CNS. Although this remodeli...
Publications
View AllOrphanin FQ: A Neuropeptide That Activates an Opioidlike G Protein-Coupled Receptor
A heptadecapeptide was identified and purified from porcine brain tissue as a ligand for an orphan heterotrimeric GTP- binding protein (G protein)- coupled receptor (LC132) that...
An excitatory amino-acid transporter with properties of a ligand-gated chloride channel
Excitatory amino-acid transporters (EAATs) in the central nervous system maintain extracellular glutamate concentrations below excitotoxic levels and may limit the activation of...
The Time Course of Glutamate in the Synaptic Cleft
The peak concentration and rate of clearance of neurotransmitter from the synaptic cleft are important determinants of synaptic function, yet the neurotransmitter concentration ...
Cloning of the cDNA and gene for a human D2 dopamine receptor.
A clone encoding a human D2 dopamine receptor was isolated from a pituitary cDNA library and sequenced. The deduced protein sequence is 96% identical with that of the cloned rat...
Kinetics of a human glutamate transporter
Currents mediated by a glutamate transporter cloned from human motor cortex were measured in Xenopus oocytes. In the absence of glutamate, voltage jumps induced Na(+)-dependent ...
Mouse Excitatory Amino Acid Transporter EAAT2: Isolation, Characterization, and Proximity to Neuroexcitability Loci on Mouse Chromosome 2
Glutamate and aspartate are excitatory neurotransmitters that have been implicated in a number of pathological states of the nervous system. Accumulation of extracellular excita...
Affiliated Researchers
Institution Info
- Type
- facility
- Country
- US
- Publications
- 7
- Citations
- 7,070
External Links
Identifiers
- ROR
- https://ror.org/054hm6j14