Philipps University of Marburg

Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) is a global health emergency. An attractive drug target a...

Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial

Understanding reactivity with Kohn-Sham molecular orbital theory: E2-SN2 mechanistic spectrum and other concepts

On the basis of Kohn–Sham density functional (DFT) investigations on elementary organic and organometallic reactions, we show how a detailed understanding of the electronic stru...

Synthetic and thermodynamic investigations in the polymerization of ethylene carbonate

Abstract The polymerization of ethylene carbonate using different metal alkoxides results in poly(oxy‐ethylene‐ alt ‐ethylene carbonate). Polymers containing low amounts of CO 2...

Molecular Characterization of Human Zyxin

Zyxin is a component of adhesion plaques that has been suggested to perform regulatory functions at these specialized regions of the plasma membrane. Here we describe the isolat...