National Institute of Diabetes and Digestive and Kidney Diseases

Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

The American Diabetes Association and the European Association for the Study of Diabetes convened a panel to update the prior position statements, published in 2012 and 2015, on...

Optimized Molecular Dynamics Force Fields Applied to the Helix−Coil Transition of Polypeptides

Obtaining the correct balance of secondary structure propensities is a central priority in protein force-field development. Given that current force fields differ significantly ...

Identification of Renox, an NAD(P)H oxidase in kidney

Oxygen sensing is essential for homeostasis in all aerobic organisms, but its mechanism is poorly understood. Data suggest that a phagocytic-like NAD(P)H oxidase producing react...

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation

A pilot study of pioglitazone treatment for nonalcoholic steatohepatitis† ‡

Nonalcoholic steatohepatitis (NASH) is a common chronic liver disease for which there is no known effective therapy. A proportion of patients with NASH progress to advanced fibr...

Are Current Molecular Dynamics Force Fields too Helical?

Chromatin Unfolds

On the nature of antibody combining sites: Unusual structural features that may confer on these sites an enhanced capacity for binding ligands

Abstract A detailed analysis of the structural aspects of antibody–antigen interactions has been made possible by the availability of X‐ray structures for three complexes of ant...

CTCF-dependent enhancer-blocking by alternative chromatin loop formation

The mechanism underlying enhancer-blocking by insulators is unclear. We explored the activity of human β-globin HS5, the orthologue of the CTCF-dependent chicken HS4 insulator. ...

Impaired Glucose Tolerance in the U. S. Population

Impaired glucose tolerance (IGT) constitutes two-thirds of all glucose intolerance in the United States and is a major risk factor for diabetes. Despite these findings, the clin...