Myriad Genetics

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene <i>BRCA1</i>

A strong candidate for the 17q-linked BRCA1 gene, which influences susceptibility to breast and ovarian cancer, has been identified by positional cloning methods. Probable predi...

<i>BRCA1</i> Mutations in Primary Breast and Ovarian Carcinomas

Loss of heterozygosity data from familial tumors suggest that BRCA1 , a gene that confers susceptibility to ovarian and early-onset breast cancer, encodes a tumor suppressor. Th...

Kcnq1ot1 Antisense Noncoding RNA Mediates Lineage-Specific Transcriptional Silencing through Chromatin-Level Regulation

Recent investigations have implicated long antisense noncoding RNAs in the epigenetic regulation of chromosomal domains. Here we show that Kcnq1ot1 is an RNA polymerase II-encod...

Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus

Regulation of p16<i>^CDKN2</i> Expression and Its Implications for Cell Immortalization and Senescence

p16CDKN2 specifically binds to and inhibits the cyclin-dependent kinases CDK4 and CDK6, which function as regulators of cell cycle progression in G1 by contributing to the phosp...

Human mitogen-activated protein kinase kinase 4 as a candidate tumor suppressor.

Mitogen-activated protein kinases function in signal transduction pathways that are involved in controlling key cellular processes in many organisms. A mammalian member of this ...

A probabilistic model for detecting coding regions in DNA sequences

A probabilistic model is presented to predict whether or not an anonymous sequence of DNA contains exons. The method is shown to be at least as reliable as Grail, a well-known n...

Localization of a putative tumor suppressor gene by using homozygous deletions in melanomas.

The p21 region of human chromosome 9 is thought to contain a gene (MLM) involved in genetic susceptibility to melanoma and a gene or genes that influence progression of certain ...

Isolation of a diverged homeobox gene, M0X1, from the BRCA1 region on 17q21 by solution hybrid capture

Using the technique of solution hybridization coupled with magnetic bead capture, we have isolated a novel homeobox-containing gene from the BRCA1 region of 17q21. This gene is ...