Alexander Kamb

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene <i>BRCA1</i>

A strong candidate for the 17q-linked BRCA1 gene, which influences susceptibility to breast and ovarian cancer, has been identified by positional cloning methods. Probable predi...

<i>BRCA1</i> Mutations in Primary Breast and Ovarian Carcinomas

Loss of heterozygosity data from familial tumors suggest that BRCA1 , a gene that confers susceptibility to ovarian and early-onset breast cancer, encodes a tumor suppressor. Th...

Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus

Isolation of a diverged homeobox gene, M0X1, from the BRCA1 region on 17q21 by solution hybrid capture

Using the technique of solution hybridization coupled with magnetic bead capture, we have isolated a novel homeobox-containing gene from the BRCA1 region of 17q21. This gene is ...

Localization of a putative tumor suppressor gene by using homozygous deletions in melanomas.

The p21 region of human chromosome 9 is thought to contain a gene (MLM) involved in genetic susceptibility to melanoma and a gene or genes that influence progression of certain ...

A P1-based physical map of the region from D17S776 to D17S78 containing the breast cancer susceptibility gene <i>BRCA1</i>

BRCA1, a breast and ovarian cancer susceptibility locus, has been isolated and maps to 17q21. A physical map of the BRCA1 region which extended from the proximal boundary at D17...