Hubrecht Institute for Developmental Biology and Stem Cell Research

The Human Cell Atlas

The recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe to complete the ...

Crypt stem cells as the cells-of-origin of intestinal cancer

The Diverse Functions of MicroRNAs in Animal Development and Disease

MicroRNA Expression in Zebrafish Embryonic Development

MicroRNAs (miRNAs) are small noncoding RNAs, about 21 nucleotides in length, that can regulate gene expression by base-pairing to partially complementary mRNAs. Regulation by mi...

Transcription Factor Achaete Scute-Like 2 Controls Intestinal Stem Cell Fate

SOX9 Is Required for the Differentiation of Paneth Cells in the Intestinal Epithelium

RAKE and LNA-ISH reveal microRNA expression and localization in archival human brain

microRNAs (miRNAs) are small (~22 nucleotide) regulatory RNAs which play fundamental roles in many biological processes. Recent studies have shown that the expression of many mi...

Expression of an <i>ASCL2</i> related stem cell signature and <i>IGF2</i> in colorectal cancer liver metastases with 11p15.5 gain

Background and aims Liver metastases are the leading cause of death in colorectal cancer. To gain better insight into the biology of metastasis and possibly identify new therape...