Centre for Cancer Biology

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data

Abstract The classification of myeloid neoplasms and acute leukemias was last updated in 2016 within a collaboration between the World Health Organization (WHO), the Society for...

Guidelines and definitions for research on epithelial–mesenchymal transition

The pathogenesis of cancer metastasis

Enzalutamide with Standard First-Line Therapy in Metastatic Prostate Cancer

Enzalutamide was associated with significantly longer progression-free and overall survival than standard care in men with metastatic, hormone-sensitive prostate cancer receivin...

Metastasis: Quantitative Analysis of Distribution and Fate of Tumor Emboli Labeled With <sup>125</sup>I-5-Iodo-2′ -deoxyuridine<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

125I-5-iodo-2′-deoxyuridine was used to label pure B16 melanoma cells grown in tissue culture. In vitro and in vivo studies established the optimal, nontoxic labeling dose. C57B...

Alterations in the p53 gene and the clonal evolution of the blast crisis of chronic myelocytic leukemia.

Molecular mechanisms responsible for the clinical progression of chronic myelocytic leukemia to its accelerated phase or to blast crisis have not been defined. We found alterati...

Increasing metastatic potential is associated with increasing genetic instability of clones isolated from murine neoplasms.

The metastatic stability of clones, which were derived from the murine UV-2237 fibrosarcoma and which exhibit low or high metastatic potential, was examined after 60-72 days of ...

Effects of Blocking Platelet-Derived Growth Factor-Receptor Signaling in a Mouse Model of Experimental Prostate Cancer Bone Metastases

Endothelial cells appear to express phosphorylated PDGF-R when they are exposed to tumor cells that express PDGF. Using STI571 to inhibit PDGF-R phosphorylation may, especially ...

Evidence that intravenously derived murine pulmonary melanoma metastases can originate from the expansion of a single tumor cell.

The purpose of these studies was to determine whether hematogenous clonal pulmonary melanoma metastases originate from the expansion of a single cell and if so, by extrapolation...