International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data

Abstract

Abstract The classification of myeloid neoplasms and acute leukemias was last updated in 2016 within a collaboration between the World Health Organization (WHO), the Society for Hematopathology, and the European Association for Haematopathology. This collaboration was primarily based on input from a clinical advisory committees (CACs) composed of pathologists, hematologists, oncologists, geneticists, and bioinformaticians from around the world. The recent advances in our understanding of the biology of hematologic malignancies, the experience with the use of the 2016 WHO classification in clinical practice, and the results of clinical trials have indicated the need for further revising and updating the classification. As a continuation of this CAC-based process, the authors, a group with expertise in the clinical, pathologic, and genetic aspects of these disorders, developed the International Consensus Classification (ICC) of myeloid neoplasms and acute leukemias. Using a multiparameter approach, the main objective of the consensus process was the definition of real disease entities, including the introduction of new entities and refined criteria for existing diagnostic categories, based on accumulated data. The ICC is aimed at facilitating diagnosis and prognostication of these neoplasms, improving treatment of affected patients, and allowing the design of innovative clinical trials.

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Affiliated Institutions

• Université Paris Cité FR
• Assistance Publique – Hôpitaux de Paris FR
• Helsinki University Hospital FI
• University Hospital Ulm DE
• University Hospital Heidelberg DE
• Centre for Cancer Biology AU
• Lurie Children's Hospital US
• Azienda Ospedaliero-Universitaria Careggi IT
• The University of Texas MD Anderson Cancer Center US
• University of Pennsylvania US
• University of Cologne DE
• Ludwig-Maximilians-Universität München DE
• Karolinska Institutet SE
• Medical University of Lodz PL
• Seattle Children's Hospital US
• Peter MacCallum Cancer Centre AU
• Texas Tech University US
• Massachusetts General Hospital US
• Kyoto University JP
• Fred Hutch Cancer Center US
• Texas Tech University Health Sciences Center US
• Universidad de Salamanca ES
• Helios Universitätsklinikum Wuppertal DE
• Augusta University Health US
• Mount Sinai Medical Center US
• University of Freiburg DE
• Dana-Farber Cancer Institute US
• The University of Texas Southwestern Medical Center US
• University of Brescia IT
• University of Pavia IT
• Universitat de Barcelona ES
• Memorial Sloan Kettering Cancer Center US
• Mayo Clinic in Arizona US
• Brigham and Women's Hospital US
• Goethe University Frankfurt DE
• University of Milan IT
• Ospedale Papa Giovanni XXIII IT
• Hôpital Saint-Louis FR
• University of New Mexico US
• University Medical Center Freiburg DE
• University of Baltimore US
• The Royal Melbourne Hospital AU
• Hospital de Sant Pau ES
• University of Oxford GB
• St. Jude Children's Research Hospital US
• Erasmus MC NL
• The Barbara Ann Karmanos Cancer Institute US
• University of Chicago US
• Stanford University US
• National Institutes of Health Clinical Center US
• Vanderbilt University US
• Dana-Farber/Boston Children's Cancer and Blood Disorders Center US
• University Medical Centre Mannheim DE
• Svenska Örtmedicinska Institute SE
• Johns Hopkins University US
• University of Washington US
• University of Florence IT
• Kettering University US
• Washington University in St. Louis US
• Heidelberg University DE
• National Taiwan University Hospital TW

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