Case Comprehensive Cancer Center

Publications

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

James Darnell , lan M. Kerr , George R. Stark

Through the study of transcriptional activation in response to interferon α (IFN-α) and interferon γ (IFN-γ), a previously unrecognized direct signal transduction pathway to the...

1994 Science 6039 citations

Krüppel-like factor 4 regulates macrophage polarization

Xudong Liao , Nikunj Sharma , Fehmida Kapadia +15 more

Current paradigms suggest that two macrophage subsets, termed M1 and M2, are involved in inflammation and host defense. While the distinct functions of M1 and M2 macrophages hav...

2011 Journal of Clinical Investigation 729 citations

Irreversible Gene Repression Model for Control of Development

Arnold I. Caplan , Charles P. Ordahl

As the pluripotent cells of early embryos differentiate, each progressively loses the potency to develop into several phenotypes. Ultimately, each cell becomes irreversibly rest...

1978 Science 118 citations

Institution Info

Type: healthcare
Country: N/A
Publications: 3
Citations: 6,886

External Links

Identifiers

ROR: https://ror.org/00fpjq451

Publications

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

Krüppel-like factor 4 regulates macrophage polarization

Irreversible Gene Repression Model for Control of Development

Affiliated Researchers

Chris A. Flask

Julian Kim

Mukesh K. Jain

Institution Info

External Links

Identifiers

Research Output Over Time