James Darnell

Cytoplasmic activation of GAF, an IFN-gamma-regulated DNA-binding factor.

Transcriptional induction by interferon. New protein(s) determine the extent and length of the induction.

Interferon (IFN) treatment of human fibroblasts induces the transcription of two genes, IFN-IND-1 and -2, to a maximal level between 30 min and 2 h. Continued exposure to IFN re...

Synergistic interaction between interferon-alpha and interferon-gamma through induced synthesis of one subunit of the transcription factor ISGF3.

Interactions of alpha- and gamma-interferon in the transcriptional regulation of the gene encoding a guanylate-binding protein.

Mapping of RNA polymerase on mammalian genes in cells and nuclei.

The assembly of an RNA polymerase II initiation complex at a promoter is associated with the melting of the DNA template to allow the polymerase to read the DNA sequence and syn...

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

Through the study of transcriptional activation in response to interferon α (IFN-α) and interferon γ (IFN-γ), a previously unrecognized direct signal transduction pathway to the...

Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transcriptional control.

Human alpha- and beta-interferons (IFNs) stimulate rapid but transient increases in transcription from a set of previously quiescent genes. Protein synthesis is not required for...