William J. Greenleaf

Chromatin accessibility and the regulatory epigenome

Physical access to DNA is a highly dynamic property of chromatin that plays an essential role in establishing and maintaining cellular identity. The organization of accessible c...

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

The chromatin accessibility landscape of primary human cancers

Cancer chromatin accessibility landscape The Cancer Genome Atlas (TCGA) provides a high-quality resource of molecular data on a large variety of human cancers. Corces et al. use...

ArchR is a scalable software package for integrative single-cell chromatin accessibility analysis

Abstract The advent of single-cell chromatin accessibility profiling has accelerated the ability to map gene regulatory landscapes but has outpaced the development of scalable s...

Nfib Promotes Metastasis through a Widespread Increase in Chromatin Accessibility