The chromatin accessibility landscape of primary human cancers

Abstract

Cancer chromatin accessibility landscape The Cancer Genome Atlas (TCGA) provides a high-quality resource of molecular data on a large variety of human cancers. Corces et al. used a recently modified assay to profile chromatin accessibility to determine the accessible chromatin landscape in 410 TCGA samples from 23 cancer types (see the Perspective by Taipale). When the data were integrated with other omics data available for the same tumor samples, inherited risk loci for cancer predisposition were revealed, transcription factors and enhancers driving molecular subtypes of cancer with patient survival differences were identified, and noncoding mutations associated with clinical prognosis were discovered. Science , this issue p. eaav1898 ; see also p. 401

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Affiliated Institutions

• Van Andel Institute US
• University of California, Santa Cruz US
• Universidade Federal do Paraná BR
• University of Virginia US
• Stanford University US
• BC Cancer Agency CA
• National Cancer Institute US
• Universidade de São Paulo BR
• Canada's Michael Smith Genome Sciences Centre CA
• Howard Hughes Medical Institute US
• University of North Carolina at Chapel Hill US
• Cedars-Sinai Medical Center US
• Chan Zuckerberg Initiative (United States) US

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