Mediation of Unusually High Concentrations of 1,25-Dihydroxyvitamin D in Homozygous<i>klotho</i>Mutant Mice by Increased Expression of Renal 1α-Hydroxylase Gene
Homozygous klotho mutant (kl-/-) mice exhibit multiple phenotypes resembling human aging. To elucidate the molecular basis of these singular phenotypes, we focused on the mechan...