Sudeep Banjade

Computed structures of core eukaryotic protein complexes

Deep learning for protein interactions The use of deep learning has revolutionized the field of protein modeling. Humphreys et al . combined this approach with proteome-wide, co...

Phase transitions in the assembly of multivalent signalling proteins

Phase separation of signaling molecules promotes T cell receptor signal transduction

Phase separation organizes signaling In T cell receptors, signaling molecules reorganize into tiny phase-separated droplets—like oil in water. Su et al. used an in vitro system ...

Phase transitions of multivalent proteins can promote clustering of membrane receptors

Clustering of proteins into micrometer-sized structures at membranes is observed in many signaling pathways. Most models of clustering are specific to particular systems, and re...