Steven P. Gygi

The impact of microRNAs on protein output

A probability-based approach for high-throughput protein phosphorylation analysis and site localization

Evaluation of two-dimensional gel electrophoresis-based proteome analysis technology

Proteome analysis is most commonly accomplished by a combination of two-dimensional gel electrophoresis (2DE) to separate and visualize proteins and mass spectrometry (MS) for p...

Proteome Analysis of Low-Abundance Proteins Using Multidimensional Chromatography and Isotope-Coded Affinity Tags

The effectiveness of proteome-wide protein identification and quantitative expression profiling is dependent on the ability of the analytical methodologies employed to routinely...

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1

Proximity labeling for investigating protein-protein interactions

Weighing in on ubiquitin: the expanding role of mass-spectrometry-based proteomics

Quantitative Proteomics of the Cancer Cell Line Encyclopedia

ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage

Cellular responses to DNA damage are mediated by a number of protein kinases, including ATM (ataxia telangiectasia mutated) and ATR (ATM and Rad3-related). The outlines of the s...