Peter S. Tobias

Structure and Function of Lipopolysaccharide Binding Protein

The primary structure of lipopolysaccharide binding protein (LBP), a trace plasma protein that binds to the lipid A moiety of bacterial lipopolysaccharides (LPSs), was deduced b...

Identification of a Lipid A Binding Site in the Acute Phase Reactant Lipopolysaccharide Binding Protein

Lipopolysaccharide (LPS) binding protein (LBP), a recently discovered 60-kDa acute phase protein, is present in the acute phase serum of many species including human, rabbits, m...

Endotoxin induces rapid protein tyrosine phosphorylation in 70Z/3 cells expressing CD14.

CD14, a glycosylphosphatidylinositol-anchored glycoprotein of leukocytes, binds endotoxin (lipopolysaccharide (LPS)) with high affinity. After the murine pre-B cell line 70Z/3 i...

Lipopolysaccharide (LPS) recognition in macrophages. Participation of LPS-binding protein and CD14 in LPS-induced adaptation in rabbit peritoneal exudate macrophages.

Exposure of rabbit peritoneal exudate macrophages (PEM) or whole blood to picomolar concentrations of LPS induces adaptation or hyporesponsiveness to LPS. Because of the importa...

CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

Leukocytes respond to lipopolysaccharide (LPS) at nanogram per milliliter concentrations with secretion of cytokines such as tumor necrosis factor-α (TNF-α). Excess secretion of...

Lipopolysaccharide-Binding Protein and CD14