Moshe Oren

mdm2 expression is induced by wild type p53 activity.

Pathways and therapeutic targets in melanoma

This review aims to summarize the current knowledge of molecular pathways and their clinical relevance in melanoma. Metastatic melanoma was a grim diagnosis, but in recent years...

A Mutant p53 That Discriminates between p53-Responsive Genes Cannot Induce Apoptosis

Human wild-type (wt) p53 can induce apoptosis in transiently transfected H1299 cells maintained at 37 degrees C, whereas tumor-derived mutant forms of p53 (with the mutation Ala...

Generation of oscillations by the p53-Mdm2 feedback loop: A theoretical and experimental study

The intracellular activity of the p53 tumor suppressor protein is regulated through a feedback loop involving its transcriptional target, mdm2 . We present a simple mathematical...

p53 and apoptosis

Wild-type p53 can inhibit oncogene-mediated focus formation.

Mutant forms of the p53 cellular tumor antigen elicit neoplastic transformation in vitro. Recent evidence indicated that loss of normal p53 expression is a frequent event in cer...

Induction of apoptosis in HeLa cells by trans-activation-deficient p53.

The p53 tumor suppressor protein is a transcriptional activator, which can mediate apoptotic cell death in a variety of cell types. To determine whether sequence-specific trans-...