Carol Prives

Identification of p53 as a Sequence-Specific DNA-Binding Protein

The tumor-suppressor gene p53 is altered by missense mutation in numerous human malignancies. However, the biochemical properties of p53 and the effect of mutation on these prop...

Wild-type p53 activates transcription in vitro

p53: puzzle and paradigm.

As the tale of p53 unfolds, it becomes ever more intriguing. Although our understanding of the critical and complex roles played by p53 is progressing rapidly, new findings cont...

Activation of p53 sequence-specific DNA bindingby short single strands of DNA requires the p53 C-terminus

Upon cellular DNA damage, the p53 tumor suppressor protein transmits a signal to genes that control the cell cycle and apoptosis. One function of p53 that is important for its r...

A Mutant p53 That Discriminates between p53-Responsive Genes Cannot Induce Apoptosis

Human wild-type (wt) p53 can induce apoptosis in transiently transfected H1299 cells maintained at 37 degrees C, whereas tumor-derived mutant forms of p53 (with the mutation Ala...