Michael E. Greenberg

Molecular Mechanisms of Neuronal Survival and Apoptosis

Transcription-dependent and -independent control of neuronal survival by the PI3K–Akt signaling pathway

Characterization of a Pathway for Ciliary Neurotrophic Factor Signaling to the Nucleus

Components of a signaling pathway that couples the ciliary neurotrophic factor (CNTF) receptor to induction of transcription were identified. CNTF stimulated the tyrosine phosph...

Regulation of transcription factors by neuronal activity

Genome-Wide Analysis of MEF2 Transcriptional Program Reveals Synaptic Target Genes and Neuronal Activity-Dependent Polyadenylation Site Selection

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

A signaling pathway was delineated by which insulin-like growth factor 1 (IGF-1) promotes the survival of cerebellar neurons. IGF-1 activation of phosphoinositide 3-kinase (PI3-...

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

Nerve growth factor and epidermal growth factor induce rapid transient changes in proto-oncogene transcription in PC12 cells.

Nerve growth factor (NGF) promotes neuronal differentiation of PC12 pheochromocytoma cells. We show here that within 5 min after its addition, NGF transiently stimulates c-fos p...

Cellular survival: a play in three Akts

The programmed cell death that occurs as part of normal mammalian development was first observed nearly a century ago (Collin 1906). It has since been established that approxima...

14-3-3 Proteins and Survival Kinases Cooperate to Inactivate BAD by BH3 Domain Phosphorylation

Survival Factor-Mediated BAD Phosphorylation Raises the Mitochondrial Threshold for Apoptosis

Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis

In the developing brain, transcription factors (TFs) direct the formation of a diverse array of neurons and glia. We identifed 1445 putative TFs in the mouse genome. We used in ...