Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis

Paul A. Gray; Hui Fu; Ping Luo; Qing Zhao; Jing Yu; Annette Ferrari; Toyoaki Tenzen; Dongin Yuk; Eric F. Tsung; Zhaohui Cai; John A. Alberta; Leping Cheng; Yang Liu; Jan M. Stenman; M. Todd Valerius; Nathan Billings; Haesun A. Kim; Michael E. Greenberg; Andrew P. McMahon; David H. Rowitch; Charles D. Stiles; Qiufu Ma

doi:10.1126/science.1104935

Abstract

In the developing brain, transcription factors (TFs) direct the formation of a diverse array of neurons and glia. We identifed 1445 putative TFs in the mouse genome. We used in situ hybridization to map the expression of over 1000 of these TFs and TF-coregulator genes in the brains of developing mice. We found that 349 of these genes showed restricted expression patterns that were adequate to describe the anatomical organization of the brain. We provide a comprehensive inventory of murine TFs and their expression patterns in a searchable brain atlas database.

Keywords

GenomeBiologyGeneTranscription factorIn situ hybridizationComputational biologyGene expressionGenetics

MeSH Terms

AnimalsAnimalsNewbornBrainCloningMolecularCorpus StriatumDNA PrimersDatabasesFactualGene Expression ProfilingGenomeHypothalamusIn Situ HybridizationMesencephalonMiceNeocortexPolymerase Chain ReactionRhombencephalonSpinal CordThalamusTranscription Factors

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Publication Info

Year: 2004
Type: article
Volume: 306
Issue: 5705
Pages: 2255-2257
Citations: 425
Access: Closed

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APA Style

                            
                                
                                    Paul A. Gray, 
                                
                                    Hui Fu, 
                                
                                    Ping Luo
                                
                                et al.
                            
                            (2004). 
                            Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. 
                            Science
                            , 306
                            (5705)
                            , 2255-2257.
                            https://doi.org/10.1126/science.1104935
                        

Identifiers

DOI: 10.1126/science.1104935
PMID: 15618518

Data Quality

Data completeness: 81%