Publications
3 shownApaf-1 Oligomerizes into Biologically Active ∼700-kDa and Inactive ∼1.4-MDa Apoptosome Complexes
Apaf-1, by binding to and activating caspase-9, plays a critical role in apoptosis. Oligomerization of Apaf-1, in the presence of dATP and cytochrome c, is required for the acti...
Caspase Activation Involves the Formation of the Aposome, a Large (∼700 kDa) Caspase-activating Complex
In mammals, apoptotic protease-activating factor 1 (Apaf-1), cytochrome c, and dATP activate caspase-9, which initiates the postmitochondrial-mediated caspase cascade by proteol...
Frequent Co-Authors
Researcher Info
- h-index
- 3
- Publications
- 3
- Citations
- 2,109
- Institution
- MRC Toxicology Unit
External Links
Identifiers
- ORCID
- 0000-0001-7910-6075
Impact Metrics
h-index
3
h-index: Number of publications with at least h citations each.