David G. Brown - Researcher Profile | RDL Research Database

Publications

2 shown

Apaf-1 Oligomerizes into Biologically Active ∼700-kDa and Inactive ∼1.4-MDa Apoptosome Complexes

Kelvin Cain , Shawn B. Bratton , Claudia Langlais +4 more

Apaf-1, by binding to and activating caspase-9, plays a critical role in apoptosis. Oligomerization of Apaf-1, in the presence of dATP and cytochrome c, is required for the acti...

2000 Journal of Biological Chemistry 315 citations

Caspase Activation Involves the Formation of the Aposome, a Large (∼700 kDa) Caspase-activating Complex

Kelvin Cain , David G. Brown , Claudia Langlais +1 more

In mammals, apoptotic protease-activating factor 1 (Apaf-1), cytochrome c, and dATP activate caspase-9, which initiates the postmitochondrial-mediated caspase cascade by proteol...

1999 Journal of Biological Chemistry 302 citations

Frequent Co-Authors

Researcher Info

h-index: 2
Publications: 2
Citations: 617
Institution: University of Leicester

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Impact Metrics

h-index 2

h-index: Number of publications with at least h citations each.