James N. Topper - Researcher Profile

Publications

2 shown

Blood flow and vascular gene expression: fluid shear stress as a modulator of endothelial phenotype

James N. Topper , Michael A. Gimbrone

Vascular endothelium, the cellular monolayer lining the entire cardiovascular system, is exposed to a variety of biochemical and biomechanical stimuli. Fluid shear stresses gene...

1999 Molecular Medicine Today 386 citations

Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress.

James N. Topper , Jiexing Cai , D Falb +1 more

Early atherosclerotic lesions develop in a topographical pattern that strongly suggests involvement of hemodynamic forces in their pathogenesis. We hypothesized that certain end...

1996 Proceedings of the National Academy o... 836 citations

Frequent Co-Authors

Researcher Info

h-index: 2
Publications: 2
Citations: 1,222
Institution: Stanford University

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h-index 2

h-index: Number of publications with at least h citations each.

Publications

Blood flow and vascular gene expression: fluid shear stress as a modulator of endothelial phenotype

Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress.

Frequent Co-Authors

Michael A. Gimbrone

Jiexing Cai

D Falb

Researcher Info

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Academic Output Over Time