Fluorine in Pharmaceuticals: Looking Beyond Intuition
Fluorine substituents have become a widespread and important drug component, their introduction facilitated by the development of safe and selective fluorinating agents. Organof...
Publications
6 shownStructures and vibrational frequencies of the carbon molecules C2-C18 calculated by density functional theory
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructures and vibrational frequencies of the carbon molecules C2-C18 calculated by density functional theoryJuerg Hutter, Hans Peter...
A Fluorine Scan at the Catalytic Center of Thrombin: CF, COH, and COMe Bioisosterism and Fluorine Effects on p<i>K</i><sub>a</sub> and log <i>D</i> Values
Abstract A series of 16 tricyclic thrombin inhibitors was prepared by using the 1,3‐dipolar cycloaddition of azomethine ylides derived from 3‐ or 4‐hydroxyproline and 4‐bromoben...
Predicting and Tuning Physicochemical Properties in Lead Optimization: Amine Basicities
Abstract This review describes simple and useful concepts for predicting and tuning the p K a values of basic amine centers, a crucial step in the optimization of physical and A...
Fluorine Interactions at the Thrombin Active Site: Protein Backbone Fragments HC<sub>α</sub>CO Comprise a Favorable CF Environment and Interactions of CF with Electrophiles
Abstract In a systematic fluorine scan of a rigid inhibitor to map the fluorophilicity/fluorophobicity of the active site in thrombin, one or more F substituents were introduced...
Orthogonal Multipolar Interactions in Structural Chemistry and Biology
Abstract The past few decades of molecular recognition studies have greatly enhanced our knowledge on apolar, ion–dipole, and hydrogen‐bonding interactions. However, much less a...
Frequent Co-Authors
Researcher Info
- h-index
- 6
- Publications
- 6
- Citations
- 7,735
- Institution
- ETH Zurich
External Links
Identifiers
- ORCID
- 0000-0003-1947-6327
Impact Metrics
h-index
6
h-index: Number of publications with at least h citations each.