Fluorine in Pharmaceuticals: Looking Beyond Intuition
Fluorine substituents have become a widespread and important drug component, their introduction facilitated by the development of safe and selective fluorinating agents. Organof...
Fluorine substituents have become a widespread and important drug component, their introduction facilitated by the development of safe and selective fluorinating agents. Organof...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructures and vibrational frequencies of the carbon molecules C2-C18 calculated by density functional theoryJuerg Hutter, Hans Peter...
Abstract A series of 16 tricyclic thrombin inhibitors was prepared by using the 1,3‐dipolar cycloaddition of azomethine ylides derived from 3‐ or 4‐hydroxyproline and 4‐bromoben...
Abstract This review describes simple and useful concepts for predicting and tuning the p K a values of basic amine centers, a crucial step in the optimization of physical and A...
Abstract In a systematic fluorine scan of a rigid inhibitor to map the fluorophilicity/fluorophobicity of the active site in thrombin, one or more F substituents were introduced...
Abstract The past few decades of molecular recognition studies have greatly enhanced our knowledge on apolar, ion–dipole, and hydrogen‐bonding interactions. However, much less a...
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