Dennis E. Discher

Mesenchymal stem cell perspective: cell biology to clinical progress

The terms MSC and MSCs have become the preferred acronym to describe a cell and a cell population of multipotential stem/progenitor cells commonly referred to as mesenchymal ste...

Minimal "Self" Peptides That Inhibit Phagocytic Clearance and Enhance Delivery of Nanoparticles

Stealth Delivery Delivery of therapeutics and imaging agents is hampered by the ability of the innate immune system to recognize and clear foreign particles. "Self" cells are pr...

Tissue Cells Feel and Respond to the Stiffness of Their Substrate

Normal tissue cells are generally not viable when suspended in a fluid and are therefore said to be anchorage dependent. Such cells must adhere to a solid, but a solid can be as...

Myotubes differentiate optimally on substrates with tissue-like stiffness

Contractile myocytes provide a test of the hypothesis that cells sense their mechanical as well as molecular microenvironment, altering expression, organization, and/or morpholo...

Substrate Compliance versus Ligand Density in Cell on Gel Responses