Substrate Compliance versus Ligand Density in Cell on Gel Responses

Adam J. Engler; Lucie Bačáková; Cynthia Newman; Alina Hategan; Maureen A. Griffin; Dennis E. Discher

doi:10.1016/s0006-3495(04)74140-5

Keywords

Substrate (aquarium)Compliance (psychology)Ligand (biochemistry)ChemistryBiophysicsMaterials scienceBiologyBiochemistryPsychologyReceptor

Affiliated Institutions

University of Pennsylvania US

Related Publications

Hydrodynamic Damage to Animal Cells

Yusuf Chisti

Animal cells are affected by hydrodynamic forces that occur in culture vessel, transfer piping, and recovery operations such as microfiltration. Depending on the type, intensity...

2001 Critical Reviews in Biotechnology 257 citations

Distinct Activation States of α5β1 Integrin Show Differential Binding to RGD and Synergy Domains of Fibronectin

Andrés J. Garcı́a , Jean E. Schwarzbauer , David Boettiger

alpha5beta1 integrin can occupy several distinct conformational states which support different strengths of binding to fibronectin [García, A. J., et al. (1998) J. Biol. Chem. 2...

2002 Biochemistry 150 citations

Solid stress inhibits the growth of multicellular tumor spheroids

Gabriel Helmlinger , Paolo A. Netti , Hera C. Lichtenbeld +2 more

In normal tissues, the processes of growth, remodeling, and morphogenesis are tightly regulated by the stress field; conversely, stress may be generated by these processes. We d...

1997 Nature Biotechnology 841 citations

Heregulin Reverses the Oligomerization of HER3

Ralf Landgraf , David Eisenberg

We analyzed the propensity of the HER3 receptor and its extracellular domain (ECD) to undergo ligand-independent self-association. The HER3-ECD, purified from Drosophila S2 cell...

2000 Biochemistry 50 citations

Relationships between Rap1b, Affinity Modulation of Integrin αIIbβ3, and the Actin Cytoskeleton

Alessandra Bertoni , Seiji Tadokoro , Koji Eto +4 more

The affinity of integrin alpha(IIb)beta(3) for fibrinogen is controlled by inside-out signals that are triggered by agonists like thrombin. Agonist treatment of platelets also a...

2002 Journal of Biological Chemistry 182 citations

Publication Info

Year: 2004
Type: article
Volume: 86
Issue: 1
Pages: 617-628
Citations: 1139
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Substrate Compliance versus Ligand Density in Cell on Gel Responses

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

1139

OpenAlex

Cite This

APA Style

                            
                                
                                    Adam J. Engler, 
                                
                                    Lucie Bačáková, 
                                
                                    Cynthia Newman
                                
                                et al.
                            
                            (2004). 
                            Substrate Compliance versus Ligand Density in Cell on Gel Responses. 
                            Biophysical Journal
                            , 86
                            (1)
                            , 617-628.
                            https://doi.org/10.1016/s0006-3495(04)74140-5
                        

Identifiers

DOI: 10.1016/s0006-3495(04)74140-5