David M. Mosser

Exploring the full spectrum of macrophage activation

Biochemical and functional characterization of three activated macrophage populations

Abstract We generated three populations of macrophages (Mφ) in vitro and characterized each. Classically activated Mφ (Ca-Mφ) were primed with IFN-γ and stimulated with LPS. Typ...

Monocyte subpopulations and their differentiation patterns during infection

Abstract The term “monocyte” implies a single, homogenous population of cells with uniform physiology. Recent evidence from a number of laboratories indicates that it is likely ...

A novel phenotype for an activated macrophage: the type 2 activated macrophage

Abstract Activated macrophages were used as antigen presenting cells (APCs) to determine the extent to which these APCs could influence an adaptive immune response. We show that...

Reversing Lipopolysaccharide Toxicity by Ligating the Macrophage Fcγ Receptors

Abstract Our laboratory has previously demonstrated that the ligation of phagocytic receptors on macrophages can influence cytokine production. In this study, we examine the cyt...

Cutting Edge: Biasing Immune Responses by Directing Antigen to Macrophage Fcγ Receptors

Abstract An immune response can deviate toward either a Th1- or Th2-like response. In this work we examine the contribution that activated macrophages and IgG Abs make toward th...

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines