Boyi Gan

Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy

Abstract The cystine/glutamate antiporter SLC7A11 (also commonly known as xCT) functions to import cystine for glutathione biosynthesis and antioxidant defense and is overexpres...

Targeting ferroptosis as a vulnerability in cancer

Ferroptosis is an iron-dependent form of regulated cell death that is triggered by the toxic build-up of lipid peroxides on cellular membranes. In recent years, ferroptosis has ...

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression

Energy-stress-mediated AMPK activation inhibits ferroptosis

Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis