The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression

Guang Lei; Yilei Zhang; Pranavi Koppula; Xiaoguang Liu; Jie Zhang; Steven H. Lin; Jaffer A. Ajani; Qin Xiao; Zhongxing Liao; Hui Wang; Boyi Gan

doi:10.1038/s41422-019-0263-3

Keywords

RadioresistanceLipid peroxidationGPX4BiologyCancer researchProgrammed cell deathCancer cellReactive oxygen speciesCancerIonizing radiationCell biologyCell cultureOxidative stressApoptosisBiochemistrySuperoxide dismutaseIrradiationGenetics

Affiliated Institutions

Related Publications

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

Matthew Dodson , Raúl Castro-Portuguez , Donna D. Zhang

The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is a key regulator of the cellular antioxidant response, controlling the expression of genes that cou...

2019 Redox Biology 2094 citations

Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis

L. Joseph Su , Jiahao Zhang , Hernando Gómez +5 more

Reactive oxygen species- (ROS-) induced lipid peroxidation plays a critical role in cell death including apoptosis, autophagy, and ferroptosis. This fundamental and conserved me...

2019 Oxidative Medicine and Cellular Longe... 1931 citations

Ferroptosis: machinery and regulation

Xin Chen , Jingbo Li , Rui Kang +2 more

Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death caused by lipid peroxidation, which is controlled by integrated oxidation and antioxidant systems. T...

2020 Autophagy 1778 citations

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

Chao Mao , Xiaoguang Liu , Yilei Zhang +10 more

2021 Nature 1549 citations

Targeting ferroptosis as a vulnerability in cancer

Guang Lei , Li Zhuang , Boyi Gan

Ferroptosis is an iron-dependent form of regulated cell death that is triggered by the toxic build-up of lipid peroxides on cellular membranes. In recent years, ferroptosis has ...

2022 Nature reviews. Cancer 1883 citations

Publication Info

Year: 2020
Type: article
Volume: 30
Issue: 2
Pages: 146-162
Citations: 1224
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

1224

OpenAlex

Cite This

APA Style

                            
                                
                                    Guang Lei, 
                                
                                    Yilei Zhang, 
                                
                                    Pranavi Koppula
                                
                                et al.
                            
                            (2020). 
                            The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression. 
                            Cell Research
                            , 30
                            (2)
                            , 146-162.
                            https://doi.org/10.1038/s41422-019-0263-3
                        

Identifiers

DOI: 10.1038/s41422-019-0263-3