The basics of epithelial-mesenchymal transition
The origins of the mesenchymal cells participating in tissue repair and pathological processes, notably tissue fibrosis, tumor invasiveness, and metastasis, are poorly understoo...
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1,290 publications
Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression
An adaption of Egger regression (which we call MR-Egger) can detect some violations of the standard instrumental variable assumptions, and provide an effect estimate which is no...
Complex heatmaps reveal patterns and correlations in multidimensional genomic data
Abstract Summary: Parallel heatmaps with carefully designed annotation graphics are powerful for efficient visualization of patterns and relationships among high dimensional gen...
Statistical significance for genomewide studies
With the increase in genomewide experiments and the sequencing of multiple genomes, the analysis of large data sets has become commonplace in biology. It is often the case that ...
TCS: a computer program to estimate gene genealogies
Phylogenies are extremely useful tools, not only for establishing genealogical relationships among a group of organisms or their parts (e.g. genes), but also for a variety of re...
UFBoot2: Improving the Ultrafast Bootstrap Approximation
The standard bootstrap (SBS), despite being computationally intensive, is widely used in maximum likelihood phylogenetic analyses. We recently proposed the ultrafast bootstrap a...
Genetic Distance between Populations
A measure of genetic distance (D) based on the identity of genes between populations is formulated. It is defined as D = -logeI, where I is the normalized identity of genes betw...
Free Radicals in the Physiological Control of Cell Function
At high concentrations, free radicals and radical-derived, nonradical reactive species are hazardous for living organisms and damage all major cellular constituents. At moderate...