Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

Keywords

Diffuse large B-cell lymphomaGerminal centerLymphomaBiologyGene expression profilingCancer researchGene expressionGeneB cellPathologyImmunologyMedicineAntibodyGenetics

Affiliated Institutions

Related Publications

A specific monoclonal antibody (PG-B6) detects expression of the BCL-6 protein in germinal center B cells.

Leonardo Flenghi , B. H. Ye , Marco Fizzotti +7 more

The BCL-6 gene is frequently involved in translocations occurring at the 3q27 locus and is rearranged in approximately 30% of diffuse large cell lymphomas and in a small fractio...

1995 PubMed 97 citations

BCL-6 EXPRESSION IN REACTIVE LYMPHOID TISSUE AND IN B-CELL NON-HODGKIN'S LYMPHOMAS

Stefania Pittaluga , Torik Ayoubi , Iwona Wlodarska +6 more

Chromosomal abnormalities involving 3q27 have recently been associated with diffuse large B-cell lymphomas and, less frequently, with follicular lymphomas. Molecular studies hav...

1996 The Journal of Pathology 47 citations

Somatic hypermutation in normal and transformed human B cells

Ulf Klien , Tina Goasens , Motthias Fischer +4 more

Summary: In the human, most IgM + IgD + as well as CD5* peripheral blood B cells express unmutated V genes and thus can be assigned to a pre‐germinal centre (GC) stage of develo...

1998 Immunological Reviews 337 citations

Accumulation of miR-155 and <i>BIC</i> RNA in human B cell lymphomas

Peggy S. Eis , Wayne Tam , Liping Sun +5 more

We show that the microRNA miR-155 can be processed from sequences present in BIC RNA, a spliced and polyadenylated but non-protein-coding RNA that accumulates in lymphoma cells....

2005 Proceedings of the National Academy o... 1314 citations

Augmented Expression of a Human Gene for 8-oxoguanine DNA Glycosylase (MutM) in B Lymphocytes of the Dark Zone in Lymph Node Germinal Centers

Frank C. Kuo , Jeffrey Sklar

B cells that mediate normal, T cell–dependent, humoral immune responses must first pass through germinal centers (GCs) within the cortex of antigenically stimulated lymph nodes....

1997 The Journal of Experimental Medicine 47 citations

Publication Info

Year: 2000
Type: article
Volume: 403
Issue: 6769
Pages: 503-511
Citations: 9829
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

9829

OpenAlex

Cite This

APA Style

                            
                                
                                    Ash A. Alizadeh, 
                                
                                    Michael B. Eisen, 
                                
                                    R. Eric Davis
                                
                                et al.
                            
                            (2000). 
                            Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. 
                            Nature
                            , 403
                            (6769)
                            , 503-511.
                            https://doi.org/10.1038/35000501
                        

Identifiers

DOI: 10.1038/35000501