Publications

Global Consequences of Land Use

Land use has generally been considered a local environmental issue, but it is becoming a force of global importance. Worldwide changes to forests, farmlands, waterways, and air ...

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

A Combined Corner and Edge Detector

The problem we are addressing in Alvey Project MMI149 is that of using computer vision to understand the unconstrained 3D world, in which the viewed scenes will in general conta...

Bioconductor: open software development for computational biology and bioinformatics

A safe operating space for humanity

An obesity-associated gut microbiome with increased capacity for energy harvest

Comprehensive molecular portraits of human breast tumours

Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments

The problem of identifying differentially expressed genes in designed microarray experiments is considered. Lonnstedt and Speed (2002) derived an expression for the posterior od...

A Practical Guide to Splines

Modularity and community structure in networks

Many networks of interest in the sciences, including social networks, computer networks, and metabolic and regulatory networks, are found to divide naturally into communities or...

clusterProfiler 4.0: A universal enrichment tool for interpreting omics data

Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring

Although cancer classification has improved over the past 30 years, there has been no general approach for identifying new cancer classes (class discovery) or for assigning tumo...