The Pfam protein families database
Pfam is a comprehensive collection of protein domains and families, represented as multiple sequence alignments and as profile hidden Markov models. The current release of Pfam ...
Publications
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216 publications
Cancer Disparities by Race/Ethnicity and Socioeconomic Status
This article highlights disparities in cancer incidence, mortality, and survival in relation to race/ethnicity, and census data on poverty in the county or census tract of resid...
Assessing the Probability That a Positive Report is False: An Approach for Molecular Epidemiology Studies
Abstract Too many reports of associations between genetic variants and common cancer sites and other complex diseases are false positives. A major reason for this unfortunate si...
Evolution and Functional Impact of Rare Coding Variation from Deep Sequencing of Human Exomes
A Deep Look Into Our Genes Recent debates have focused on the degree of genetic variation and its impact upon health at the genomic level in humans (see the Perspective by Casal...
Effect of Angiotensin-Converting Enzyme Inhibition and Angiotensin II Receptor Blockers on Cardiac Angiotensin-Converting Enzyme 2
Background— Angiotensin-converting enzyme 2 (ACE2) has emerged as a novel regulator of cardiac function and arterial pressure by converting angiotensin II (Ang II) into the vaso...
Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults
In this small study involving older adults, adverse events associated with the mRNA-1273 vaccine were mainly mild or moderate. The 100-μg dose induced higher binding- and neutra...
Overdiagnosis in Cancer
This article summarizes the phenomenon of cancer overdiagnosis-the diagnosis of a "cancer" that would otherwise not go on to cause symptoms or death. We describe the two prerequ...
GeneMark.hmm: new solutions for gene finding
The number of completely sequenced bacterial genomes has been growing fast. There are computer methods available for finding genes but yet there is a need for more accurate algo...
Large Shareholders as Monitors: Is There a Trade‐Off between Liquidity and Control?
This paper analyzes the incentives of large shareholders to monitor public corporations. We investigate the hypothesis that a liquid stock market reduces large shareholders' inc...
Structure and Interpretation of Computer Programs
"The Structure and Interpretation of Computer Programs" is the entry-level subject in Computer Science at the Massachusetts Institute of Technology. It is required of all studen...