Finishing the euchromatic sequence of the human genome
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genom...
Publications
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1,212 publications
Global Biodiversity: Indicators of Recent Declines
Global Biodiversity Target Missed In 2002, the Convention on Biological Diversity (CBD) committed to a significant reduction in the rate of biodiversity loss by 2010. There has ...
Thrombectomy within 8 Hours after Symptom Onset in Ischemic Stroke
Among patients with anterior circulation stroke who could be treated within 8 hours after symptom onset, stent retriever thrombectomy reduced the severity of post-stroke disabil...
Reading digits in natural images with unsupervised feature learning
Detecting and reading text from natural images is a hard computer vision task that is central to a variety of emerging applications. Related problems like document character rec...
Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China
Cardiac injury is a common condition among hospitalized patients with COVID-19 in Wuhan, China, and it is associated with higher risk of in-hospital mortality.
Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes
Age-related clonal hematopoiesis is a common condition that is associated with increases in the risk of hematologic cancer and in all-cause mortality, with the latter possibly d...
Ipilimumab plus Dacarbazine for Previously Untreated Metastatic Melanoma
Ipilimumab (at a dose of 10 mg per kilogram) in combination with dacarbazine, as compared with dacarbazine plus placebo, improved overall survival in patients with previously un...
Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma
These findings define a genetic basis for benefit from CTLA-4 blockade in melanoma and provide a rationale for examining exomes of patients for whom anti-CTLA-4 agents are being...