Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

2014 New England Journal of Medicine 4,444 citations

Abstract

Age-related clonal hematopoiesis is a common condition that is associated with increases in the risk of hematologic cancer and in all-cause mortality, with the latter possibly due to an increased risk of cardiovascular disease. (Funded by the National Institutes of Health and others.).

Keywords

Somatic cellHaematopoiesisHematologic NeoplasmsHematologic disordersIncidence (geometry)Somatic evolution in cancerHematologyMedicineGermline mutationMutationOncologyImmunologyCancerGeneInternal medicineBiologyGeneticsStem cell

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Publication Info

Year
2014
Type
article
Volume
371
Issue
26
Pages
2488-2498
Citations
4444
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Siddhartha Jaiswal, Pierre Fontanillas, Jason Flannick et al. (2014). Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes. New England Journal of Medicine , 371 (26) , 2488-2498. https://doi.org/10.1056/nejmoa1408617

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DOI
10.1056/nejmoa1408617