Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence

Abstract

Clonal hematopoiesis with somatic mutations is readily detected by means of DNA sequencing, is increasingly common as people age, and is associated with increased risks of hematologic cancer and death. A subset of the genes that are mutated in patients with myeloid cancers is frequently mutated in apparently healthy persons; these mutations may represent characteristic early events in the development of hematologic cancers. (Funded by the National Human Genome Research Institute and others.).

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Affiliated Institutions

• Science for Life Laboratory SE
• Massachusetts General Hospital US
• University of Gothenburg SE
• Center for Systems Biology US
• Harvard University US
• Stanley Center for Psychiatric Research
• Karolinska University Hospital SE
• Uppsala University Hospital SE
• Massachusetts Institute of Technology US
• Broad Institute US
• Memorial Sloan Kettering Cancer Center US
• Icahn School of Medicine at Mount Sinai US
• University of North Carolina at Chapel Hill US
• Stanley Foundation US
• Karolinska Institutet SE
• Genomics (United Kingdom) GB

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