Gene-Expression Profiles in Hereditary Breast Cancer
Significantly different groups of genes are expressed by breast cancers with BRCA1 mutations and breast cancers with BRCA2 mutations. Our results suggest that a heritable mutati...
Publications
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128 publications
On convection cells induced by surface tension
A mechanism is proposed by which cellular convective motion of the type observed by H. Bénard, which hitherto has been attributed to the action of buoyancy forces, can also be i...
Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults
In this small study involving older adults, adverse events associated with the mRNA-1273 vaccine were mainly mild or moderate. The 100-μg dose induced higher binding- and neutra...
A Systematic Survey of Loss-of-Function Variants in Human Protein-Coding Genes
Defective Gene Detective Identifying genes that give rise to diseases is one of the major goals of sequencing human genomes. However, putative loss-of-function genes, which are ...
Establishing rigour in qualitative research: the decision trail
The aim of this paper is to show the way in which the decision trail of a qualitative research process can be maintained. It is argued that the trustworthiness (rigour) of a stu...
Rape Trauma Syndrome
The authors interviewed and followed 146 patients admitted during a one-year period to the emergency ward of a city hospital with a presenting complaint of having been raped. Ba...
The Surviving Sepsis Campaign: Results of an international guideline-based performance improvement program targeting severe sepsis*
The Campaign was associated with sustained, continuous quality improvement in sepsis care. Although not necessarily cause and effect, a reduction in reported hospital mortality ...