Twelve years of SAMtools and BCFtools
Abstract Background SAMtools and BCFtools are widely used programs for processing and analysing high-throughput sequencing data. They include tools for file format conversion an...
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1,314 publications
A new coronavirus associated with human respiratory disease in China
Emerging infectious diseases, such as severe acute respiratory syndrome (SARS) and Zika virus disease, present a major threat to public health1–3. Despite intense research effor...
Knowledge of the Firm, Combinative Capabilities, and the Replication of Technology
How should we understand why firms exist? A prevailing view has been that they serve to keep in check the transaction costs arising from the self-interested motivations of indiv...
SWISS-MODEL: homology modelling of protein structures and complexes
Homology modelling has matured into an important technique in structural biology, significantly contributing to narrowing the gap between known protein sequences and experimenta...
Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding
In late December, 2019, patients presenting with viral pneumonia due to an unidentified microbial agent were reported in Wuhan, China. A novel coronavirus was subsequently ident...
Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer
Anti-PD-1 antibody produced objective responses in approximately one in four to one in five patients with non-small-cell lung cancer, melanoma, or renal-cell cancer; the adverse...
Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments
The problem of identifying differentially expressed genes in designed microarray experiments is considered. Lonnstedt and Speed (2002) derived an expression for the posterior od...
Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring
Although cancer classification has improved over the past 30 years, there has been no general approach for identifying new cancer classes (class discovery) or for assigning tumo...