The Sequence of the Human Genome
A 2.91-billion base pair (bp) consensus sequence of the euchromatic portion of the human genome was generated by the whole-genome shotgun sequencing method. The 14.8-billion bp ...
Publications
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1,130 publications
A Global Geometric Framework for Nonlinear Dimensionality Reduction
Scientists working with large volumes of high-dimensional data, such as global climate patterns, stellar spectra, or human gene distributions, regularly confront the problem of ...
Limited-dependent and qualitative variables in econometrics
This book presents the econometric analysis of single-equation and simultaneous-equation models in which the jointly dependent variables can be continuous, categorical, or trunc...
Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
The Gene Expression Omnibus (GEO) project was initiated in response to the growing demand for a public repository for high-throughput gene expression data. GEO provides a flexib...
A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic Molecules
Abstract: We present the derivation of a new molecular mechanical force field for simulating the structures, conformational energies, and interaction energies of proteins, nucle...
Consumer Perceptions of Price, Quality, and Value: A Means-End Model and Synthesis of Evidence
Evidence from past research and insights from an exploratory investigation are combined in a conceptual model that defines and relates price, perceived quality, and perceived va...
Knowledge of the Firm, Combinative Capabilities, and the Replication of Technology
How should we understand why firms exist? A prevailing view has been that they serve to keep in check the transaction costs arising from the self-interested motivations of indiv...
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
lin-4 is essential for the normal temporal control of diverse postembryonic developmental events in C. elegans. lin-4 acts by negatively regulating the level of LIN-14 protein, ...
SWISS-MODEL: homology modelling of protein structures and complexes
Homology modelling has matured into an important technique in structural biology, significantly contributing to narrowing the gap between known protein sequences and experimenta...