Comprehensive molecular profiling of lung adenocarcinoma
Adenocarcinoma of the lung is the leading cause of cancer death worldwide. Here we report molecular profiling of 230 resected lung adenocarcinomas using messenger RNA, microRNA ...
Publications
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266 publications
Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2
How SARS-CoV-2 binds to human cells Scientists are racing to learn the secrets of severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2), which is the cause of the pandemi...
The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans
Expression, genetic variation, and tissues Human genomes show extensive genetic variation across individuals, but we have only just started documenting the effects of this varia...
The Origins of Totalitarianism
Essai philosophique en trois parties, la premiere sur l'antisemitisme, la deuxieme sur l'imperialisme a la fin du XIXe s., la troisieme sur le totalitarisme stalinien et nazi
Accurate prediction of protein structures and interactions using a three-track neural network
Deep learning takes on protein folding In 1972, Anfinsen won a Nobel prize for demonstrating a connection between a protein’s amino acid sequence and its three-dimensional struc...
Dissecting racial bias in an algorithm used to manage the health of populations
Racial bias in health algorithms The U.S. health care system uses commercial algorithms to guide health decisions. Obermeyer et al. find evidence of racial bias in one widely us...
The Limits to Growth
Every person approaches problems with the help of models. A model is simply an ordered set of assumptions about a complex system. Our world model was built specifically to inves...
Chemical Management for Colorful, Efficient, and Stable Inorganic–Organic Hybrid Nanostructured Solar Cells
Chemically tuned inorganic-organic hybrid materials, based on CH3NH3(═MA)Pb(I(1-x)Br(x))3 perovskites, have been studied using UV-vis absorption and X-ray diffraction patterns a...
A point‐charge force field for molecular mechanics simulations of proteins based on condensed‐phase quantum mechanical calculations
Abstract Molecular mechanics models have been applied extensively to study the dynamics of proteins and nucleic acids. Here we report the development of a third‐generation point...
Competition for competence and interpartner learning within international strategic alliances
Global competition highlights asymmetries in the skill endowments of firms. Collaboration may provide an opportunity for one partner to internalize the skills of the other, and ...
WEIRD languages have misled us, too [Comment on Henrich et al.]
The linguistic and cognitive sciences have severely underestimated the degree of linguistic diversity in the world. Part of the reason for this is that we have projected assumpt...
RAxML-NG: a fast, scalable and user-friendly tool for maximum likelihood phylogenetic inference
Abstract Motivation Phylogenies are important for fundamental biological research, but also have numerous applications in biotechnology, agriculture and medicine. Finding the op...