Publications
Explore 300 academic publications
Laplacian Eigenmaps for Dimensionality Reduction and Data Representation
One of the central problems in machine learning and pattern recognition is to develop appropriate representations for complex data. We consider the problem of constructing a rep...
Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
The pathophysiological process of Alzheimer's disease (AD) is thought to begin many years before the diagnosis of AD dementia. This long “preclinical” phase of AD would provide ...
Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials
Funnel plots, and tests for funnel plot asymmetry, have been widely used to examine bias in the results of meta-analyses. Funnel plot asymmetry should not be equated with public...
Planetary Boundaries: Exploring the Safe Operating Space for Humanity
"Anthropogenic pressures on the Earth System have reached a scale where abrupt global environmental change can no longer be excluded. We propose a new approach to global sustain...
Oxidants, antioxidants, and the degenerative diseases of aging.
Metabolism, like other aspects of life, involves tradeoffs. Oxidant by-products of normal metabolism cause extensive damage to DNA, protein, and lipid. We argue that this damage...