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Climate Change 2022 – Impacts, Adaptation and Vulnerability
The Working Group II contribution to the Sixth Assessment Report of the Intergovernmental Panel on Climate Change (IPCC) provides a comprehensive assessment of the scientific li...
A General Theory of Crime
Preface Part I. Crime: 1. Classical theory and the idea of crime 2. The nature of crime Part II. Criminality: 3. Biological positivism 4. Psychological, economic, and sociologic...
First Case of 2019 Novel Coronavirus in the United States
An outbreak of novel coronavirus (2019-nCoV) that began in Wuhan, China, has spread rapidly, with cases now confirmed in multiple countries. We report the first case of 2019-nCo...
Pembrolizumab plus Chemotherapy in Metastatic Non–Small-Cell Lung Cancer
In patients with previously untreated metastatic nonsquamous NSCLC without EGFR or ALK mutations, the addition of pembrolizumab to standard chemotherapy of pemetrexed and a plat...
Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction
BACKGROUND In patients with type 2 diabetes, inhibitors of sodium-glucose cotransporter 2 (SGLT2) reduce the risk of a first hospitalization for heart failure, possibly through ...
Cancer immunotherapy using checkpoint blockade
The release of negative regulators of immune activation (immune checkpoints) that limit antitumor responses has resulted in unprecedented rates of long-lasting tumor responses i...